The ultimate la platform for Systems Biology

The laboratory applies systems biology approaches to understand the molecular mechanisms of infectious diseases and vaccine-induced immunity.



Systems Immunology

With the technological revolutions that occurred in the past decades, we are now able to access and integrate information about all the components within a biological system (e.g., genes, proteins, cells) and use it to compute and predict that system’s behavior. When applied to immunology, systems biology approaches can help us to understand the mechanisms by which pathogens and vaccines stimulate protective immunity.


Research

lncRNAs

It is estimated that thousands of long non-coding RNAs (lncRNAs) are transcribed in the genome of several organisms. Yet, only a small fraction of them have been functionally characterized. Studying the expression profile of lncRNAs and how their expression correlates with the expression of protein-coding genes in various tissues and conditions will reveal interesting mechanisms of gene regulation. 


Tools

sysbio.tools

Our laboratory has developed several user-friendly tools and databases for those that have no bioinformatics background.


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People

Our research is performed by a multidisciplinary team of students and collaborators.


Education

Courses, workshops and lectures related to bioinformatics and systems biology.


Blog

Latest news and papers related to Computational Systems Biology.





A conference to promote women’s research in computational biology

The first Advances in Computational Biology conference will bring together researchers working on systems biology, omics technologies, artificial intelligence


June 11, 2019  Blog Interesting

FBC0519 2019 – Imunodiagnóstico

FACULDADE DE CIÊNCIAS FARMACÊUTICASDepartamento de Análises Clínicas e Toxicológicas – 2016FBC0519: Imunodiagnóstico – Integral e Noturno (4 créditos) Professores:Joilson de

May 24, 2019  Classes


Network Medicine

“Given the functional interdependencies between the molecular components in a human cell, a disease is rarely a consequence of an

May 23, 2019  Research

FBC0416 Fisiopatologia II (2019)

Créditos Aula:4Créditos Trabalho:0Tipo:Semestral ObjetivosO aluno deve ser capaz de descrever a fisiopatologia das principais doenças que afetam o sistema nervoso,


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What we can do, forNetwork Medicine

By CSBL Research

“Given the functional interdependencies between the molecular components in a human cell, a disease is rarely a consequence of an abnormality in a single gene, but reflects the perturbations of the complex intracellular and

May 23, 20190


Tools and Databases

By CSBL Research

These are the tools and databases developed by our group. We have created webtools, R packages and scripts in Python, Perl, C, and even Alexa skills to allow non-bioinformaticians to perform advanced systems biology

June 7, 20161


Long non-coding RNAs

By CSBL Research

  It is estimated that thousands of long non-coding RNAs (lncRNAs) are transcribed in the genome of several organisms. Yet, only a small fraction of them have been functionally characterized. One of the main

November 30, 20130


Systems Vaccinology

By CSBL Research 1 Comment

Systems vaccinology Copyright: Immunity. 2010 Oct 29;33(4):516-29.   Systems vaccinology has recently emerged as an interdisciplinary field that combines systems-wide measurements, networks and predictive modeling in the context of vaccinology. For centuries, vaccines were

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